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Projects & Research
New Technologies for Metabolomics Jay Keasling, Principal Investigator (LBNL, Physical Biosciences Division) The goals of this project are to develop methods for profiling metabolites and metabolic fluxes in microbes of DOE interest, and to develop strategies for perturbing metabolite levels and fluxes in order to study the influence of changes in metabolism on cellular function. The project involves identifying and measuring a wide range of metabolites in the presence of electron receptors, then identifying the genes associated with the involved metabolic pathways. The metabolic flux data will then be integrated with information from the annotated genomes of the microbes to better predict the effects of environmental changes on cell physiology and metal and actinide reduction. |
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